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■ The Novel Synthesis of 5-Cyano-1-azabicyclo[3.3.0]octane

Mituru Oka, Yukiharu Matsumoto,* and Ryoichi Unno

*Drug Discovery Research Department, Sanwa Kagaku Kenkyusho, 363 shiosaki, Hokusei-cho, Inabe-gun, Mie, 511-04, Japan

Abstract

5-Cyano-1-azabicyclo[3.3.0]octane (1), which is a key intermediary material to some medicines, was prepared from 1,7-dichloroheptan-4-one (7) via only one step under mild conditions. The reaction mechanism is also discussed.