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Communication | Regular issue | Vol 45, No. 8, 1997, pp.1447-1450
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7845
The Novel Synthesis of 5-Cyano-1-azabicyclo[3.3.0]octane

Mituru Oka, Yukiharu Matsumoto,* and Ryoichi Unno

*Drug Discovery Research Department, Sanwa Kagaku Kenkyusho, 363 shiosaki, Hokusei-cho, Inabe-gun, Mie, 511-04, Japan


5-Cyano-1-azabicyclo[3.3.0]octane (1), which is a key intermediary material to some medicines, was prepared from 1,7-dichloroheptan-4-one (7) via only one step under mild conditions. The reaction mechanism is also discussed.