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Paper | Regular issue | Vol 45, No. 9, 1997, pp.1687-1702
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7827
Renewable Functionalized Pyridines Derived from Microbial Metabolites of the Alkaloid (S)-Nicotine

Jean-Paul Roduit, Alain Wellig, and Andreas Kiener*

*Department of Process Research, LONZA Ltd., P.O. box CH-3930 Visp, Switzerland


(S)-Nicotine, which is present in concentrations of 2-8% in dried leaves of certain tobacco plants, was used as a starting material for the biocatalytic production of renewable functionalized pyridines. Key microbial metabolites of (S)-nicotine, such as 6-hydroxy-(S)-nicotine and 4-[(6-hydroxypyridine)-3-yl]-4-oxobutyrate were used in subsequent chemical steps for the preparation of a wide variety of 2,5-di- or 2,3,5-tri-substituted pyridines.