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Paper | Regular issue | Vol 45, No. 8, 1997, pp.1509-1518
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7823
Syntheses of New Pyrazolo[3,4-d]-pyrimidine Derivatives Starting from 1,1-Diamino-2,2-dicyanoethylene

Richard Neidlein* and Zhijun Wang

*Pharmazeutisch-Chemishces Institut, Universität Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany

Abstract

3,4-Diamino-6-dimethylamino-1-methylpyrazolo[3,4-d]pyrimidine (4) was prepared from the reaction of 6-amino-4-choro-5-cyano-2-dimethylaminopyrimidine (3) with methylhydrazine. It reacted further with different aldehydes giving a variety of new pyrazolo[3,4-d]pyrimidine derivatives.