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Paper | Regular issue | Vol 45, No. 7, 1997, pp.1299-1308
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7805
Synthesis of Methyl 2-Acetylamino-5-(1,3-dithian-2-yl)thiazole-4-carboxylate

Lidia Feliu, Wadi Ajana, John A. Joule, Francisco López-Calahorra, and Mercedes Alvarez*

*Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Av. de Joan XXIII, s/n, 08028 Barcelona, Spain


The synthesis of methyl 2-acetylamino-5-(1,3-dithian-2-yl)thiazole-4-carboxylate (4) by formylation of a 4-substituted thiazole and then reaction with 1,3-propanedithiol are described. The utility of different ortho-directing groups (ODGs) for the lithiation of the thiazole 4-position has been studied