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Paper | Regular issue | Vol 45, No. 8, 1997, pp.1493-1507
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7788
Synthesis of 5(10→9)abeo-Ergolines

Sergio Mantegani,* Emanuele Arlandini, Daniela Borghi, Enzo Brambilla, and Mario Varasi

*Pharmacia & Upjohn, C.N.S. Research, Viale Pasteur 10-20014 Nerviano (Milan), Italy

Abstract

Reaction of the (5R,8R)-ergoline derivative (6) with the couple CCl4/(Ph)3P unexpectedly resulted in the formation of the novel (5S,8R)-5 (10 → 9)abeo-ergoline derivative. A mechanism of this transposition process is proposed.