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Communication | Regular issue | Vol 45, No. 5, 1997, pp.851-855
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7777
Novel Heterocyclic Enediynes. Molecular Design, Chemical Synthesis and DNA Cleavage

Kazunobu Toshima,* Kiyoshi Ohishi, Miho Tomishima, and Shuichi Matsumura

*Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku Yokohama 223-8522, Japan


The novel 10-membered oxaenediyne (4a) and azaenediynes (5a-d) were designed and synthesized in a short procedure, and the azaenediynes (5a-d) were found to effectively cleave DNA under both weakly acidic and basic conditions with no additive.