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Paper | Regular issue | Vol 45, No. 4, 1997, pp.723-734
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7736
Synthesis of 1-[ω-[(Arylamino)carbonyl]-alkyl]-4-(benzocycloalkyl)piperazines

Youssef El-Ahmad, Philippe Maillet, Elisabeth Laurent, Akram Talab, Gilles Tran, and Roland Ollivier*

*Centre de Recherche, Coorpération Pharmaceutique Française, 13, rue Benjamin Franklin, 77000 La Rochette, France


A series of 1-[ω-[(arylamino)carbonyl]alkyl]-4-(benzocycloalkyl)piperazines (1a-v) was prepared either by reacting the precursor 4-[ω-[(arylamino)carbonyl]alkyl]piperazine (2a-j) with 1-chlorobenzocycloalkanes (3a-c) (Procedure A) or by reacting the N-aryl-ω-chloroalkanamides (5a-j) with the 4-(benzocycloalkyl)piperazines (10a-c) (Procedure B). The best yields were obtained using procedure A.