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■ Synthesis of New Arylethanolamine and Aryloxypropanolamine Derivatives Including 1,4-Benzodioxine Moiety

Sophie Boyé, Gérald Guillaumet, and Marie-Claude Viaud*

*Institute de Chimie Organique et Analytique, associe au CNRS, Université d'Orléans, B.P. 6759, Rue de Chartres, 45067 Orleans Cedex 2, France

Abstract

The synthesis of new arylethanolamines and aryloxypropanolamines variously substituted on the nitrogen atom are described. Access to these compounds, which are potential β₃-adrenergic ligands, involves, as key step, a reductive amination reaction between 2-amino alcohols and 1,4-benzodioxine aldehyde derivatives.