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Paper | Regular issue | Vol 45, No. 5, 1997, pp.897-910
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7696
A Novel Method of Preparation of 3-Acylimidazo[1,2-a]pyridines

Jean-Luc Moutou, Martine Schmitt, Valérie Collot, and Jean-Jacques Bourguignon*

*Laboratoire de Pharmacochimie Moleculaire, Faculte de Pharmacie, ULP, 74, route du Rhin 67401 ILLKIRCH Cedex, France


A series of 2-substituted 3-acylimidazo[1,2-a]pyridines were synthesized in good to moderate yields from secondary amidino ketones and bromine in acetic acid. Cyclocondensation of the α-bromo-β-amidino ketones (6) led to the corresponding trans-dihydroimidazoles (13), which may yield spontaneously the stable 3-acylimidazo[1,2-a]pyridines (2) after dehydrogenation.