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Note | Regular issue | Vol 45, No. 6, 1997, pp.1161-1167
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7690
Electron Deficient Flavin as Catalyst for Baeyer-Villiger Reaction: Oxidation of Cyclobutanones to γ-Lactones Using Hydrogen Peroxide

Claudio Mazzini, Jacques Lebreton, and Roland Furstoss*

*Groupe Biocatalyse et Chimie Fine, ERS 157 associee au CNRS, Faculté des Sciences de Luminy, 163 Avenue de Luminy, 13288 Marseille Cedex 9, France


The use of an electron deficient isoalloxazine derivative as coenzyme model for the Baeyer-Villiger oxidation is described. This allows, in the presence of hydrogen peroxide, the catalytic oxidation of cyclobutanones into the corresponding γ-lactones with good excellent yields.