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Communication | Regular issue | Vol 45, No. 2, 1997, pp.235-240
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7682
2-Bromo-2-nitropropane/Zn Promoted Reductive Cyclizations of Ortho-substituted Nitroarenes toward 2,1-Benzisoxazole Derivatives

Byeong Hyo Kim,* Young Moo Jun, Tae Kyu Kim, Yoon Seok Lee, Woonphil Baik, and Byung Min Lee

*Department of Chemistry, Research Institute of Basic Science, Kwangwoon University, 447-1, Wolgye-Dong Nowon-ku, Seoul, 139-701, Korea


Under the mild conditions, reductive cyclizations of 2-nitrobenzaldehydes or 2’-nitroacetophenone towards 2,1-benzisoxazoles were accomplished in the presence of 2-bromo-2-nitropropane/Zn in methanolic solution. The synthetic utility and the role of 2-bromo-2-nitropropane were investigated.