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Paper | Regular issue | Vol 45, No. 2, 1997, pp.339-346
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7680
A Simple and Efficient Synthetic Method for Fluorine-containing Benzo[h]qunolines

Etsuji Okada,* Hiroshi Tone, Norikado Tsukushi, Yoshihiro Otsuki, Hiroshi Takeuchi, and Masaru Hojo

*Department of Chemical Science and Engineerring, Faculty of Engineering, Kobe University, Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan


N-Propargyl-2,4-bis(trifluoroacetyl)-1-naphthylamine (2), prepared from N,N-dimethyl-2,4-bis(trifluoroactyl)-1-naphthylamine (1) and propargylamine, undergoes ring forming reaction with amines, thiolates and alcoholates under mild conditions to afford the corresponding 6-trifluoroacetyl-4-trifluoromethylbenzo[h]quinolines (3) in excellent yields.