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Paper | Regular issue | Vol 45, No. 5, 1997, pp.875-888
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7672
Synthesis of N-Substituted 2,4-Diaminothiazoles and Their Salts

Ronald Flaig and Horst Hartmann*

*Fachbereich Chemie und Umweltingenieurwesen, Fachhochschule Merseburg, Geusaer Str., D-06217 Merseburg, Germany


A series of N(2),N(4)-subsituted 2,4-diaminothiazoles (22) and their corresponding mineral acid salts (22·HX) and (22·2HX) have been prepared by the reaction of POCl3 with N-substituted S-(dialkylaminocarbonylmethylene)isothiouronium salts (20) available from corresponding substituted thioureas (18) and N,N-disubstituted chloroacetamides (19) or by the reaction of primary or secondary amines (25) in excess with N(2)-unsubstituted or N(2)-disubstituted 2-amino-4-thiazolinimine hydrochlorides (24) availabe by the reaction of corresponding N-substituted thioureas (18) with chloroacetonitirle (23).