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Paper | Regular issue | Vol 45, No. 2, 1997, pp.309-314
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7657
Alkylation of Pyrazolones via the Mitsunobu Reaction

Wolfgang Holzer,* Brigitte Plagens, and Karin Lorenz

*Institute of Pharmaceutical Chemistry, University of Vienna, Währinger Strasse 10, A-1090 Vienna, Austria


The reaction of 3-methyl-1-phenyl-2-pyrazolin-5-one and 4-acyl derivatives thereof (R4 = COPh, 2-thienoyl, COCH2CH2Ph, COCH=CHPh) with various alcohols under ’Mitsunobu’-conditions was studied. In many cases selective O-alkylation could be achieved.