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Paper | Regular issue | Vol 45, No. 1, 1997, pp.119-127
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7647
Synthesis and the Skraup Reaction of Amino-5H-benzothiopyrano[2,3-b]pyridin-5-ones

Hidetoshi Fujiwara*

*Niigata College of Pharmacy, 5-13-2 Kamishin'ei-cho, Niigata 950-2081, Japan


The New amino derivatives of 5H-[1] benzothiopyrano [2,3-b] pyridin-5-one were synthesized. The Skraup reaction of these amino-5H- [1] benzothiopyrano [2,3-b] pyridin-5-ones was conducted in the presence of grycerol, fuming sulfuric acid, nitrobenzene, iron (II) sulfate and boric acid. 6-Amino-, 7-amino-, 8-amino- and 9-Amino-5H-[1] benzothiopyrano [2,3-b] pyridin-5-ones gave 12H-pyrido [3’,2’:5,6]thiopyrano [2,3-h] quinolin-12-one, 12H-pyrido [3’,2’:5,6] thiopyrano [3,2-f] quinolin-12-one, 7H-pyrido [3’,2’:5,6] thiopyrano [3,2-h] quinolin-7-one, respeectively.