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Paper | Regular issue | Vol 45, No. 1, 1997, pp.107-118
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7640
Synthesis of Pyrido[2,3-b]pyrazines from Pyrido[2,3-c]furoxan

Tohru Takabatake, Tomoyuki Miyazawa, and Minoru Hasegawa*

*College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan

Abstract

The synthesis of substituted pyrido[2,3-b]pyrazines was carried out. Pyrido[2,3-b]pyrazine 1,4-dioxides (3) and pyrido[2,3-b]pyrazine 1-oxides (4) were obtained from pyrido[2,3-c]furoxan (1) and 1,3-diketones or β-keto esters catalyzed by silica gel, alumina, or molecular sieves.