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Paper | Regular issue | Vol 45, No. 1, 1997, pp.77-85
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7617
Synthesis of 2-Hydroxymethyl-3,5-dimethyl-4-methoxypyridine : A Key Intermediate for Omeprazole

Shan-Yen Chou* and Shyh-Fong Chen

*Deparatment of Medicinal Chemistry, Development Center for Biotechnology, Hsi-Chih Research Park 102, Lane 169, Kang Ning St, Hsi Chih 221, Taipei Hsien, Taiwan, R.O.C.


A synthesis of 2-hydroxymethyl-3,5-dimethyl-4-methoxypyridine, a key intermediate for the preparation of gastric acid inhibiting compound omeprazole, is described. The procedure consists of preparation of pyrone, pyridone and pyridine derivatives sequentially.