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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Paper | Regular issue | Vol 45, No. 1, 1997, pp.77-85
Published online, 1st January, 1970■ Synthesis of 2-Hydroxymethyl-3,5-dimethyl-4-methoxypyridine : A Key Intermediate for Omeprazole
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7617
■ Synthesis of 2-Hydroxymethyl-3,5-dimethyl-4-methoxypyridine : A Key Intermediate for Omeprazole
Shan-Yen Chou* and Shyh-Fong Chen
*Deparatment of Medicinal Chemistry, Development Center for Biotechnology, Hsi-Chih Research Park 102, Lane 169, Kang Ning St, Hsi Chih 221, Taipei Hsien, Taiwan, R.O.C.
Abstract
A synthesis of 2-hydroxymethyl-3,5-dimethyl-4-methoxypyridine, a key intermediate for the preparation of gastric acid inhibiting compound omeprazole, is described. The procedure consists of preparation of pyrone, pyridone and pyridine derivatives sequentially.
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