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■ Studies with Plant Cell Cultures of Cassia didymobotrya. VII. Enzyme Catalyzed Biotransformation of Dibenzylbutanolides to Podophyllotoxin Analogues and Related Compounds

Bruno Botta, Giuliano Delle Monache, Paola Ricciardi, Alberto Vitali, Vittorio Vinciguerra, Domenico Misiti, James P. Kutney, and Nikolay Stoynov

*Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver B.C., V6T 1Z1, Canada

Abstract

Enzyme-catalyzed cyclizations of synthetic dibenzylbutanolides to analogues of the podophyllotoxin family are described. The biotransformations utilize enzymes derived from Cassia didymobotrya cell cultures and previously synthesized debenzylbutanolides with differ in functionality in order to evaluate the course of the cyclization process. The application of this methodology provides additional informations relating to the utilization of such "substrates" in the future synthesis of the anti-cancer drug, Etoposide, via a combination of synthetic chemistry and biotechnological methods.