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Paper | Regular issue | Vol 43, No. 10, 1996, pp.2249-2256
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7566
Synthesis of 1-Isopropylamino-3-(pyrazolo[1,5-a]pyridyloxy)-2-propanols

Yasuyoshi Miki, Junko Tasaka, Kyoko Uemura, Kunihiro Miyazeki, and Jun Yamada

*Faculty of Pharmaceutical Sciences, Kinki University, 3-4-1, Kowakae, Higashi-Osaka 577-8502, Japan


Treatment of the 4-hydroxypyrazolo[1,5-a]pyridine with glycidyl tosylate in the presence of base, followed by reaction with isopropylamine gave 1-isopropylamino-3-(pyrazolo[1,5-a]pyrid-4-yloxy)-2-propanol. In a similar manner, 1-isopropylamino-3-(pyrazolo[1,5-a]pyrid-6- and 1-isopropylamino-3-(pyrazolo[1,5-a]pyrid-3-yloxy)-2-propanol were also prepared.