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Paper | Regular issue | Vol 43, No. 12, 1996, pp.2595-2606
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7559
Stereospecific Approaches to C-12 Substituted Pyrrolo[1',2':2,3]pyridazino[6,1-a]isoindolones

Stefan Marchalin and Bernard Decroix

*Laboratoire de Chimie, Faculté des Sciences et Techniques, Université du Havre, 25, rue Philippe Lebon, BP 540, 76600 Le Havre Cedex, France


Isomerization of the cis-alcohol (2) to the trans-alcohol (3) was achieved by treatment with sodium ethoxide in ethanol solution. Various trans-C12 substituted productss (5-10) are prepared from alcohols (2), (3). On the other hand, cis-N,N-dimethylamino compound (14) was obtained in a three steps sequence from the acetic derivative (11).