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Paper | Regular issue | Vol 43, No. 10, 1996, pp.2199-2204
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7548
First Example of a 4-Amino-1,2,4,6-thiatriazine 1,1-Dioxide Derivative

Carmen Ochoa, Angela Herrero, Rafael Provencio, Jan Balzarini, Erik De Clercq, Alicia Gómez-Barrio, Rafael Martinez Díaz, and Juan José Nogal

*Instituto de Química Médica, C. S. I. C., Calle Juan de Cierva, 3, 28006 Madrid, Spain


For teh first time, an N4-amino derivative of 1,2,4,6-thiatriazine 1,1-dioide (5) was prepared by cyclocondensation reaction of the appropriate sulfamoylcarbamate (3) with hydrazine. Reaction of 3 with ammonia yielded the cyclic 4H-derivative (4). Nucleophilic substitution reactions of 4 and 5 with hydrazine, as well as comdensation of 5 with ethyl orthoformate were achieved. The antiprotozoal and anti-HIV properties of the new compounds were evaliated, but none of them showed significant biological activities.