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Communication | Regular issue | Vol 43, No. 9, 1996, pp.1855-1858
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7537
Preparations of 1-Hydroxyindole Derivatives and Their Potent Inhibitory Activities on Platelet Aggregation

Masanori Somei,* Koji Yamada, Masakazu Hasegawa, Mutsuko Tabata, Yoshiyuki Nagahama, Harunobu Morikawa, and Fumio Yamada

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan

Abstract

1-Hydroxymelatonin, 5-bromo- and 5,7-dibromo-1-hydroxytryptamine derivatives, 1,4-dihydroxy-5-nitroindole, 1-hydroxy-3-methylsulfinylmethylindole, and 5-acetyl-1,3,4,5-tetrahydro-1-hydroxypyrrolo[4,3,2-de]quinoline were synthesized for the first time. 1-Hydroxyindoles reveraled potent inhibitory activities on platelet aggregation.