Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 43, No. 8, 1996, pp.1607-1612
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7515
Absolute Stereochemistries of Giganin and Longanin, Bioactive Non-tetrahydrofuran Ring Annonaceous Acetogenins from Asimina longifolia

Qing Ye, Jerry L. McLaughlin,* and Dean Evert

*Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, 1333 Robert E. Heine Pharmacy Building West Lafayette IN 47907, Indiana 47907, U.S.A.


Two cytotoxic Annonaceous aetogenins, giganin (1) and longanin (2), were isolated from the leaves and twings of Asimina longifolis (Annonaceae). These compounds represented the type of Annonaceous astogenin lacking either tetrahydrofuran or epoxide rings along the aliphatic chain. Compound (2) is novel and giganin is previously known. The planar structures and absolute configurations of both were elucidated by 1H and 13C nmr and ms before and after certain chemical derivatizations. Compound (2) gave cytotoxic ED50 values comparable to those of adriamycin in a panel of human solid tumor cell lines.