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Paper | Regular issue | Vol 43, No. 8, 1996, pp.1767-1770
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7512
A New Route for the Synthesis of 3-Methoxythiophenes

Jaime Lissavetzky* and Ignacio Manzanares

*Instituto de Química Médica, C. S. I. C., Calle Juan de Cierva, 3, 28006 Madrid, Spain

Abstract

A new synthesis of 4-substituted, 5-substituted and 4,5-disubstituted 3-methoxythiophenes is reported. The reaction takes place in three steps in nearly quantitative yields starting from methyl 3-hydroxythiophene-2-carboxylates.