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Paper | Regular issue | Vol 43, No. 7, 1996, pp.1513-1519
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7494
Novel Violet Pigment, Nostocine A, an Extracellular Metabolite from Cyanobacterium Nostoc spongiaeforme

Kazumasa Hirata, Hirofumi Nakagami, Jun Takashina, Taifo Mahmud, Motomasa Kobayashi, Yasuko In, Toshimasa Ishida, and Kazuhisa Miyamoto*

*Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Toyonaka, Osaka 560-0043, Japan


A freshwater cyanobacterium, Nostoc spobgiaeforme TISTR 8169, produced and excreted a novel violet pigment, nostocine A (1), which had board-spectrum of growth inhibitory activity. The chemical structure of 1 was determined as 6-methyl-1,3,6,7,8-pentaazabicyclo[4.3.0]nonan-1,3,5(7)-trien-9-one on the bases of physicochemical evidence and an X-ray crystallographic analysis.