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Communication | Regular issue | Vol 43, No. 7, 1996, pp.1385-1390
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7481
■ Total Synthesis of (+)-7-Deoxypancratistatin and (+)-7-Deoxy-trans-dihydronarciclasine

Noritaka Chida,* Makoto Jitsuoka, Yoshiyuki Yamamoto, Masami Ohtsuka, and Seiichiro Ogawa

*Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku Yokohama 223-8522, Japan

Abstract

The chiral and stereoselective synthesis of antimitotic phenanthridone alkaloids, (+)-7-deoxypancratistatin (1) and (+)-7-deoxy-trans-dihydronarciclasine (2) is described. Both natural products were synthsized from common compound (4), which had been prepared from D-glucose and employed for the synthesis of lycoricidine (3).