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Paper | Regular issue | Vol 43, No. 10, 1996, pp.2113-2123
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7476
Total Synthesis of Amphimedine

Shinsuke Nakahara, Yoshihiro Tanaka, and Akinori Kubo

*Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan

Abstract

The cytotoxic fused pentacyclic aromatic alkaloid, amphimedine (2) from a Pacific sponge, was synthesized employing hetero Diels-Alder reacions.