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Paper | Regular issue | Vol 43, No. 7, 1996, pp.1483-1496
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7474
Synthesis of Acetamido(indol-3-yl)propanol Derivatives

Martha S. Morales-Ríos, L. Gerardo Zepeda, Oscar R. Suárez-Castillo, and Pedro Joseph-Nathan*

*Departmento de Química del Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, Apartado 14-740, México, D.F., 07000, Mexico, D.F.

Abstract

A series of acetamido(indol-3-yl)propanol derivatives (5-7) has been synthesized using a variety of reductive reactions performed on the corresponding O-methyl oximes of an indol-3-yl ester and of several indol-3-yl alcohol derivatives. The O-methyl oximes were prepared in good yields by acylation of the corresponding zinc salt of indole, followed by O-methyl oximation.