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Paper | Regular issue | Vol 43, No. 7, 1996, pp.1439-1446
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7444
A Short Total Synthesis of Palonosetron Using Catalytic Hydrogenation

Bruce A. Kowalczyk

*Chemical Development, Syntex Research, Palo Alto, California 94304, U.S.A.


The 5-HT3 receptro antagonists (1) and (2) (palonosetron) were synthesized by anefficient new route. The critical hydrogenation of imide (4) was carried out with either Pd/C catalyst or PtO2 catalyst.