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Paper | Regular issue | Vol 43, No. 8, 1996, pp.1621-1632
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7443
Synthesis and Antimalarial Activity of New 4,6-Dialkoxy- and 4,6-Bis(alkylthio)pyrido[3,2-g]quinoline Derivatives

Carole Matias, Abdallah Mahamoud, Jacques Barbe, Bruno Pradines, and Jean-Claude Doury

*Faculte de Pharmacie, 27, Bd Jean-Moulin 13385 Marseille Cedex 5, France


A set of 4,6-dialkoxy- and 4,6-bis(alkylthio)pyrido[3,2-g]quinoline derivatives was prepared from 2,8,10-trimethylpyrido[3,2-g]quinoline-4,6-dione as starting material. The latter was synthesized in a simple and convenient two step procedure. These compounds were tested in vitro on chloroquinosusceptible and chloroquinoresistant strains of Plasmodium falciparum. Two of them possess a 50% inhibitory concentration (IC50) lower than 100nM against both strains.