HETEROCYCLES

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

■ Synthesis and Antimalarial Activity of New 4,6-Dialkoxy- and 4,6-Bis(alkylthio)pyrido[3,2-g]quinoline Derivatives

Carole Matias, Abdallah Mahamoud, Jacques Barbe, Bruno Pradines, and Jean-Claude Doury

*Faculte de Pharmacie, 27, Bd Jean-Moulin 13385 Marseille Cedex 5, France

Abstract

A set of 4,6-dialkoxy- and 4,6-bis(alkylthio)pyrido[3,2-g]quinoline derivatives was prepared from 2,8,10-trimethylpyrido[3,2-g]quinoline-4,6-dione as starting material. The latter was synthesized in a simple and convenient two step procedure. These compounds were tested in vitro on chloroquinosusceptible and chloroquinoresistant strains of Plasmodium falciparum. Two of them possess a 50% inhibitory concentration (IC₅₀) lower than 100nM against both strains.