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Paper | Regular issue | Vol 43, No. 5, 1996, pp.1073-1081
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7433
A Synthesis of New Pyrido[2',3': 4,5]thieno[2,3-c]pyridazine Derivatives

Ma. Carmen Veiga, José Ma. Quintela,* and Carlos Peinador

*Departamento de Química Fundamental e Industrial, Facultad de Ciencias, Universidad de La Coruña, Campus de A Zapateira, E-15071, La Coruña, Spain


5-Amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carbaldehyde is formed by DIBAL reduction from the corresponding cyano precursor 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carbonitrile (1). A variety of substituted pyrido[2’,3’:4,5]thieno[2,3-c]pyridazines were synthesized from 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carbaldehyde (2) by Friedländer condensation with acyclic cyclic, heterocyclic or α,β-unsatured ketones and other active methylene compounds.