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Communication | Regular issue | Vol 43, No. 5, 1996, pp.937-940
Published online, 1st January, 1970
DOI: 10.3987/COM-96-7418
A Facile Synthesis of 4,4-Bis(trifluoromethyl)imidazolines via a Novel Oxidative Imidazole Rearrangement

Hui-Yin Li *, Indawati Delucca, Spence Drummond, and George A. Boswell

*The DuPont Merck Pharmaceutical Company, Chemical Sciences Division Experimental Station, Wilmington, DE 19880-0353, U. S. A.


Oxidation of imidazole (1) with singlet oxygen or m-chloroperbenzoic acid affords novel 4,4-bis(trifluoromethyl)imidazolines in high yield via a unique oxidative ring opening and subsequent acid catalyzed dehydrocyclization.