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Communication | Special issue | Vol 42, No. 2, 1996, pp.517-523
Published online, 1st January, 1970
DOI: 10.3987/COM-95-S83
Novel Nonprostanoid Prostacyclin (PGI2) Mimetics with Heterocyclic Moiety

Yuuki Nagao, Kanji Takahashi, Kazuhiko Torisu, Kigen Kondo, and Nobuyuki Hamanaka

*Minase research Institute, Ono Pharmaceutical Co., Ltd., Shimamoto, Mishima, Osaka 618, Japan


Structural modification of [2-(2-benzhydryloxyiminopentyl)-1,2,3,4-tetrahydro-5-naphthyloxy]acetic acid (4), previously identified as a PGI2 agonist without a PG skeleton, was examined. Conversion of the oxime moiety in 4 to the pyrazole led to [2-(4-benzhydrylpylazoyl)methyl-1,2,3,4-tetrahydro-5-naphthyloxy]acetic acid (34) which strongly inhibited ADP-induced aggregation of human platelets in vitro.