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Communication | Special issue | Vol 42, No. 2, 1996, pp.513-516
Published online, 1st January, 1970
DOI: 10.3987/COM-95-S82
Novel Indole-Ring Construction Method for the Synthesis of 2-Trifluoromethylidoles

Kazuyuki Miyashita, Katsutoshi Tsuchiya, Katsunori Kondoh, Hideto Miyabe, and Takeshi Imanishi

*Faculty of Pharmaceutical Science, Osaka University, 1-6 Yamadaoka, Toyonaka, Osaka 560-0043, Japan


Novel indole-ring construction method, which is particularly effective for the synthesis of 2-perfluoroalkylindoles, and introduction of a cyanomethyl group at C-3 of 2-perfluoroalkylindoles by means of the Mannich reaction are described.