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Communication | Special issue | Vol 42, No. 2, 1996, pp.499-502
Published online, 1st January, 1970
DOI: 10.3987/COM-95-S78
Practical Radical Deoxygenation of Erythromycins by Barton Reaction

Tsutomu Sato, Hiroshi Koga, and Koichi Tsuzukli

*Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Company, Ltd., 135, 1-Chome Komakado, Gotemba City, shizuoka 412-8513, Japan

Abstract

Practical radical deoxygenation method of erythromycins was established. Macrolide-type motilin receptor agonist GM-665 (1) has been prepared using this method.