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Communication | Special issue | Vol 42, No. 2, 1996, pp.489-492
Published online, 1st January, 1970
DOI: 10.3987/COM-95-S72
The Mechanism of Configuration Retention in the Substitution Reaction of C4-Tosyloxyproline with Lithium Diarylcuprate

Kimiko Hashimoto, Yukio Shima, and Haruhisa Shirahama*

*Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan

Abstract

The mechanism of configuration retention during the substitution reaction of C4-tosyloxyproline with lithium diarylcuprate was studied. Among the three possible intermediates (a~c), c has been found to be the origin of the retention mechanism.