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Communication | Special issue | Vol 42, No. 1, 1996, pp.165-168
Published online, 1st January, 1970
DOI: 10.3987/COM-95-S66
Cyclobutane Strategy for the Synthesis of A-Ring Aromatic Trichothecanes

Hideo Nemoto, Junji Miyata, and Keiichiro Fukumoto

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

A novel synthesis of A-ring aromatic trichothecane (2) by the regiocontrolled cyclization of 5-hydroxy-2-(2-methoxymethoxy-4-methylphenyl)-2-methyl-1-methylidenecyclopentane (10), which was prepared via the 2-phenylcyclobutanone (6) and cyclobutanols (7 and 8) and the 2-methylidene-3-phenylcyclopentanone (9), was achieved.