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Paper | Special issue | Vol 42, No. 1, 1996, pp.319-324
Published online, 1st January, 1970
DOI: 10.3987/COM-95-S38
Tenuilobine - A New Polyamine Alkaloid from Oncinotis tenuiloba

Martin K. -H. Doll, Armin Guggisberg, and Manfred Hesse

*Organisch-chemisches Institut, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland


A new cross-linked polyamine alkaloid, named tenuilobine (1), was isolated from the leaves of Oncinotis tenuiloba (Apocynaceae), the structure was established by spectroscopic means. It is the first natural alkaloid containing spermine and spermidine as polyamine parts. Presumably, compound (1) is involved in the biosynthesis of the macrocyclic spermidine alkaloids with lactam groups.