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Communication | Special issue | Vol 42, No. 1, 1996, pp.109-112
Published online, 1st January, 1970
DOI: 10.3987/COM-95-S33
Chiral Synthesis of Phosphodiesterase Inhibitor, (R)-(-)-Rolipram, by Means of Enantioselective Deprotonation Strategy

Toshio Honda, Fumihiro Ishikawa, Kazuo Kanai, Shigeki Sato, Daishiro Kato, and Hideo Tominaga

*Institute of Medicinal Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan


Enantioselective synthesis of the antidepressant (R)-(-)-rolipram (1) has been achieved by using an enantioselective deprotonation of the cyclobutanone derivative as a key step.