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Paper | Special issue | Vol 42, No. 2, 1996, pp.577-588
Published online, 1st January, 1970
DOI: 10.3987/COM-95-S32
Synthetic Studies of Novel 5-Azacarbapenems

Kuniyuki Oda, Takao Nakano, Hiroshi Morimoto, and Norio Takamura

*Organic Chemistry Research Laboratory, Tanabe Seiyaku Co.Ltd., 2-2-50, Kawagishi, Toddda, Saitama 335-8505, Japan


1,2-Diazetidiiones were prepared from (2R, 3R)-epoxybutanoic acid via acidic one-pot deprotection-cyclization reaction and converted to the novel 5-azacarbapenams by an intramolecular Michael cyclization reaction.