Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Special issue | Vol 42, No. 1, 1996, pp.289-304
Published online, 1st January, 1970
DOI: 10.3987/COM-95-S26
Synthesis of Novel Heterocycle-fused Furo[3,4-d]isoxazoles via Ring Transformation of 2-Isoxazoline-2-oxides by Lewis Acid

Kazuho Harada, Eisuke Kaji, Kuniaki Sasaki, and Shonosuke Zen

*School of Pharmaceutical Sciences, Kitasato University, Shirokane, Minato-ku, Tokyo 108-8641, Japan

Abstract

Reaction of five-membered heterocycle-substituted 2-isoxazoline-2-oxides (2, 3, and 4) with titanium tetrachloride afforded novel heterocycle-fused furo[3,4-d]isoxazoles (5, 6 and 7), respectively. This transformation was applied to indole-substituted 2-isoxazoline-2-oxide (8) to give the corresponding fused furo[3,4-d]isoxazole (9) and indolo[2,3-b]-1-pyrroline-1-oxide (10).