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Communication | Special issue | Vol 42, No. 1, 1996, pp.65-69
Published online, 1st January, 1970
DOI: 10.3987/COM-95-S20
An Enantioconvergent Construction of the Key Intermediate of (+)-Vincamine

Takahiro Yamane, Michiyo Ishizaki, Mahito Suzuki, Michiyasu Takahashi, Kou Hiroya, Seiichi Takano, and Kunio Ogasawara

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

A key intermediate for the synthesis of (+)-vincamine, the major alkaloid of Vinca minor and an important cerebral vasodilatory agent, has been synthesized in an enantioconvergent way from either (R)- or (S)-enantiomer of 2-carbethoxy-2-cyclopenten-1-ol obtained by lipase-mediated resolution.