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Paper | Regular issue | Vol 43, No. 3, 1996, pp.675-683
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7358
The Diastereoselective Synthesis of Oxacephams from 1,3-2H-Oxazines

Mostafa Hatam, Sabine Köpper, Jürgen Martens*

*Fachbereich Chemie, Universität Oldenburg, P. O. Box 2503, D-26111 Oldenburg, Germany

Abstract

Various oxacephams are obtained from symmetrically and unsymmetrically 2,2,5,5-substituted 1,3-2H-oxazines by the Staudinger reaction. The annulation reaction proceeds diastereoselectively with both synthons, as unequivocally determined by nmr spectroscopical analysis.