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Communication | Regular issue | Vol 43, No. 3, 1996, pp.531-534
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7356
Synthesis of a Carbon-linked CMP-NANA Analog and Its Inhibitory Effects on GM3 and GD3 Synthases

Yasumaru Hatanaka*, Makoto Hashimoto, Kazuya I.-P. Jwa Hidari, Yutaka Sanai, Yoshitaka Nagai, and Yuichi Kanaoka

*Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-01, Japan


A carbon-linked analog of cytidine monophospho-N-acetylneuraminic acid (CMP-NANA) was synthesized as the degradation resistant inhibitor for sialyltransferases. The compound is the first example of synthetic CMP-NANA analog that exhibited inhibitory effects on the activity of GM3 and GD3 synthases.