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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Communication | Regular issue | Vol 43, No. 3, 1996, pp.531-534
Published online, 1st January, 1970■ Synthesis of a Carbon-linked CMP-NANA Analog and Its Inhibitory Effects on GM3 and GD3 Synthases
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7356
■ Synthesis of a Carbon-linked CMP-NANA Analog and Its Inhibitory Effects on GM3 and GD3 Synthases
Yasumaru Hatanaka*, Makoto Hashimoto, Kazuya I.-P. Jwa Hidari, Yutaka Sanai, Yoshitaka Nagai, and Yuichi Kanaoka
*Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-01, Japan
Abstract
A carbon-linked analog of cytidine monophospho-N-acetylneuraminic acid (CMP-NANA) was synthesized as the degradation resistant inhibitor for sialyltransferases. The compound is the first example of synthetic CMP-NANA analog that exhibited inhibitory effects on the activity of GM3 and GD3 synthases.
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