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Paper | Regular issue | Vol 43, No. 3, 1996, pp.665-674
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7355
Synthesis and Biological Activity of Arthrographol and Related Compounds

Muneharu Miyake, Yoshiaki Hanaoka, Yasuo Fujimoto *, Yoshio Sato, Naoki Taketomo, Itsuro Yokota, and Yoshihiro Yoshiyama

*College of Pharmacy, Nihon University, Narashinodai 7-7-1, Funabashi, Chiba 274, Japan


(±)-Arthrographol (1a) and related compounds were synthesized and their inhibitory activities against 5-lipoxygenase were investigated. The 1’(Z)-isomer (1b) of arthrographol was found to be three times active than arthrographol itself.