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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Communication | Regular issue | Vol 43, No. 3, 1996, pp.519-522
Published online, 1st January, 1970■ Synthesis and Characterization of Novel Photoreactive Naltrexone Analogs as Isomeric Carbene-generating Probes for Opioid Receptors
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7345
■ Synthesis and Characterization of Novel Photoreactive Naltrexone Analogs as Isomeric Carbene-generating Probes for Opioid Receptors
Yasumaru Hatanaka,* Norio Nakamura, Miwa Wakabayashi, Toshiyuki Fujioka, and Tohru Kikuchi
*Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Toyama 930-01, Japan
Abstract
A convenient synthesis of m- and p-CF3-diazirinylbenzoic acid was developed. A pair of novel photoaffinity probes bearing these diazirines on a naltrexyl framework bind reversibly with high affinity at μ-, δ, and κ-receptors.
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