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Communication | Regular issue | Vol 43, No. 3, 1996, pp.519-522
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7345
Synthesis and Characterization of Novel Photoreactive Naltrexone Analogs as Isomeric Carbene-generating Probes for Opioid Receptors

Yasumaru Hatanaka,* Norio Nakamura, Miwa Wakabayashi, Toshiyuki Fujioka, and Tohru Kikuchi

*Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Toyama 930-01, Japan


A convenient synthesis of m- and p-CF3-diazirinylbenzoic acid was developed. A pair of novel photoaffinity probes bearing these diazirines on a naltrexyl framework bind reversibly with high affinity at μ-, δ, and κ-receptors.