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Paper | Regular issue | Vol 43, No. 3, 1996, pp.601-610
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7320
An Alternative Method for Lactonization of β,γ-Enoic Acids and its Application to Verticillene-10-carboxylic Acid

Yoshihiro Yaguchi, Mitsuhiro Akiba, Makoto Harada, and Tadahiro Kato*

*Department of Chemistry, Faculty of Science, Science University of Tokyo, Kagurazaka 1-3, Shinjuku-ku, Tokyo 162, Japan


The reaction with iodine in refluxing acetic acid was found to be an alternative method for the lactonization of β,γ-enoic acids. Application of the method to verticillene-10-carboxylic acid (6) resulted in the formation of three γ-lactones (7, 12, and 13), 12 being an unexpected product.