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Paper | Regular issue | Vol 43, No. 2, 1996, pp.415-423
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7301
Practical Synthesis of (R)-1-Benzyl-3-hydroxy-2,5-pyrrolidinedione and Its Acetate from L-Tartaric Acid

Hiroshi Tomori, Hiroshi Maruyama, and Katsuyuki Ogura*

*Department of Applied Chemistry, Faculty of Engineering, Chiba University, 1-33 Yayoicho, Inage-ku, Chiba 263, Japan

Abstract

An efficient method for preparing (R)-1-benzyl-3-hydroxy-2,5-pyrrolidinedione and its acetate is described starting from L-tartaric acid, which affords the desired compounds with 99% ee in good overall yields (63-74%).