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Paper | Regular issue | Vol 43, No. 3, 1996, pp.581-588
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7296
Isoflavan Derivatives from Glycyrrhiza glabra (Licorice)

Takeshi Kinoshita,* Kiichiro Kajiyama, Yukio Hiraga, Kunio Takahashi, Yukiyoshi Tamura, and Kenji Mizutani

*Faculty of Pharmaceutical Sciences, Teikyo University, 1091-1 Suarashi, Sagamiko-machi, Tsukui-gun, Kanagawa 199-01, Japan


A new isoflavan was isolated from the root of Glycyrrhiza glabra (licorice; Fabaceae), and its structure was elucidated as 8-prenyl-phaseollinisoflavan on the basis of spectroscopic evidence. Five known isoflavans have also been isolated, and identified with glabridin, 4’-O-methylglabridin, hispaglabridins A, B and what was previously elucidated as "3’-methoxyglabridin". The structure of the latter compound was revised to 3’-hydroxy-4’-O-methylglabridin by an irradiation experiment and long range 13C-1H COSY spectral analysis.