Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 43, No. 2, 1996, pp.267-270
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7274
Stereoselective Intramolecular Michael Reaction of the 18-Membered α,β-Unsaturated Macrolactam: MM2 Transition Structure Models

Haruo Yamada, Takashi Takahashi*, Yutaka Kanda, Yutaka Saitoh, and Tohru Fukuyama

*Department of Chemical Engineering, Tokyo Institute of Technology, Meguro, Tokyo 152, Japan


Intramolecular Michael reaction of the 18-membered α,β-unsaturated lactam, a key reaction in the total synthesis of leinamycin (1), and a discussion of its high diastereoselectivity based on MM2 transition structure models are presented.